Their structure and interactions define cellular processes and are therefore critical to our understanding how cells work and how diseases can be cured.
Proteins are the active ingredient of life
Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible.
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Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible.
Learn more
Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible.
Learn more
Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible.
Learn more
The AlphaLink2 paper is now online! It’s joint work with @rbolab and @JorgStulke. AlphaLink2 integrates crosslinking MS data into AlphaFold-Multimer. AlphaLink2 really shines for challenging targets like antigen-antibody complexes. https://doi.org/10.1038/s41467-024-51771-2
We got an ERC synergy grant to work on and understand with Julia Mahamid (EMBL), Jan Kosinsky (EMBL), and Rachel Green (Johns Hopkins University, USA) ribosomes inside their cellular context and develop tools to study molecular processes inside cells at atomic resolution.
In collaboration with the @rbolab, we are pleased to present AlphaLink2 - a modified version of AlphaFold-Multimer that is capable of directly incorporating experimental residue-residue contact data from crosslinking MS (and potentially other techniques as well). (1/7)
We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.
